We are happy to release the first public version of our new research tool, KIARVA, described in detail in Corcoran et al. Immunity 2026. Please visit our introduction and instruction videos and note that you can find Frequently Asked Questions (FAQs) under “Additional information” in the top menu.
KIARVA - Adaptive Immune Receptor Gene Variant Atlas
Welcome to KIARVA
Variation between individuals and populations within the genomic loci encoding adaptive immune receptor genes (immunoglobulin (IG) and T cell receptor (TCR)) involves both structural and allelic diversity. The first release of the Karolinska Institutet Adaptive Immune Receptor Gene Variant Atlas — KIARVA — hosts validated germline-encoded IG heavy chain (IGH) alleles identified in 2486 individuals from the 1000 Genomes Project (1KGP) collection.
For more information about KIARVA, see the pages Methodology, FAQ and About.
News
The genes of the immunoglobulin heavy chain (IGH) locus are critical for the formation of antibodies. Previous studies using limited numbers of individuals have indicated that IG germline genes are highly variable between persons. In Corcoran et al., we present a novel method for high-throughput sequencing of the functional adaptive immune genes located in complex genomic regions, and we utilize this technique to genotype 2486 individuals from the 1KGP population set, comprising 25 sub-populations.