Variation between individuals and populations within the immunoglobulin (IG) locus involves both structural and allelic diversity. The Karolinska Institutet Adaptive Immune Receptor Gene Variant Atlas (KIARVA) hosts germline-encoded IG heavy chain (IGH) alleles identified in 2486 individuals from the 1000 Genomes Project (1KGP) collection, in total 561 IGHV, 51 IGHD and 12 IGHJ alleles. KIARVA is open source and provides downloadable FASTA files with all sequences, as well as information about the frequency of each IGHV allele in 5 continental superpopulations and 25 subpopulations. As soon as possible, KIARVA will be extended to also contain population-based information about IG kappa and lambda genes, as well as T cell receptor genes.

When using this database, please cite Corcoran et al. Immunity 2026. The resource should not be used for commercial purposes. For questions, please contact the authors.

We are happy to release the first public version of our new research tool, KIARVA. Please visit our introduction and instruction videos and note that you can find Frequently Asked Questions (FAQs) under “Additional information” in the top menu.