Variation between individuals and populations within the immunoglobulin (IG) locus involves both structural and allelic diversity. The Karolinska Institutet Adaptive Immune Receptor Gene Variant Atlas (KIARVA) hosts germline-encoded IG heavy chain (IGH) alleles identified in 2485 individuals from the 1000 Genomes Project (1KGP) collection, in total 479 IGHV, 10 IGHJ and 40 IGHD alleles. KIARVA is open source and provides downloadable FASTA files with all sequences, as well as information about the frequency of each allele in 5 superpopulations and 25 subpopulations. In the near future, KIARVA will be extended to also contain population-based information about IG kappa and lambda genes, as well as T cell receptor genes. When using this database, please cite Corcoran et al. BioRxivXX, and when using the resource for commercial purposes, contact the authors.
Date: 2024-11-13
We are excited to introduce the light version of our new research tool, designed to provide an early glimpse into the DSN's first dashboard. This preliminary release includes a few example plots to showcase the tool's analytical capabilities, while the full functionality is being finalized. In this light version, users can explore data visualizations but won't have access to download FASTA files at this stage. The complete tool, including all data and download options, will be available once the research team has published their findings.
